Lack of PKCθ Promotes Regenerative Ability of Muscle Stem Cells in Chronic Muscle Injury
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چکیده
منابع مشابه
Regenerative potential of human muscle stem cells in chronic inflammation
INTRODUCTION Chronic inflammation is a profound systemic modification of the cellular microenvironment which could affect survival, repair and maintenance of muscle stem cells. The aim of this study was to define the role of chronic inflammation on the regenerative potential of satellite cells in human muscle. METHODS As a model for chronic inflammation, 11 patients suffering from rheumatoid ...
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Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main prope...
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and -4) as well as the angiogenic and anti-angiogenic factors (VEGF and sFLT-1). Interestingly, it has been observed that female MDSCs (F-MDSCs) can more efficiently regenerate the dystrophic skeletal muscle of mdx mice (a mouse model of Duchenne muscular dystrophy) than their male MDSCs (M-MDSCs) counterparts. Moreover, M-MDSCs when compared to F-MDSCs have been shown to be superior at bone an...
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Background Currently, clinical endodontics includes procedures that are based on the ability of stem cells to accomplish repair (eg, direct pulp capping, apexogenesis, apexification, and even pulpal regeneration). An attempt is made to critically assess the current status in pulp regeneration therapy. Methods: Systematically, 2 distinctly different strategies exist involving stem cells for t...
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Muscle regeneration in the adult occurs in response to damage at expenses of a population of adult stem cells, the satellite cells. Upon injury, either physical or genetic, signals released within the satellite cell niche lead to the commitment, expansion and differentiation of the pool of muscle progenitors to repair damaged muscle. To achieve this goal satellite cells undergo a dramatic trans...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21030932